2020, 28 October 2020 | Molecules, Vol. 175, 30 July 2020 | International Journal of Molecular Sciences, Vol. 2, 20 March 2020 | Antibiotics, Vol. We found that collagen is more expressed in burn wounds after topical TWEAK administration. In the granulation tissue, mesenchymal cells are maximally activated, cells proliferate, and synthesize huge amounts of extracellular matrix. Fibroblasts are the most common cells of connective tissue in animals. 14, No. In addition to the secretion of the ECM, (myo)fibroblasts, by secreting matrix metalloproteinases and tissue inhibitors of metalloproteinases, are able to remodel this ECM. Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care. Extracellular matrix plays a pivotal role in fibroblast activation, wound contraction, and tissue remodeling during skin wound repair . 8, 29 December 2016 | International Urogynecology Journal, Vol. 10, No. 38, No. Fibroblasts in the Tumor Microenvironment: Shield or Spear? 61, 29 August 2019 | Wound Repair and Regeneration, Vol. 11, No. 19, No. 2 68, No. To see this illustration in color, the reader is referred to the web version of this article at. Tissue Eng. 4, 24 July 2018 | Scientific Reports, Vol. HHS 1, 1 January 2019 | RSC Advances, Vol. 3, 31 December 2018 | ACS Applied Bio Materials, Vol. 21, No. 3, 21 September 2018 | Advanced Science, Vol. 1, 29 October 2018 | ACS Applied Materials & Interfaces, Vol. Matricellular proteins do not contribute to the mechanical structure of the ECM but instead act as paracrine signaling molecules. 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